A study published Tuesday in the Journal of the American Medical Association found that people who take at least one of the 200 drugs that list depression as a side-effect are, in fact, more likely to be depressed. The study, which included 26,192 adults who participated in the National Health and Nutrition Examination Survey, does not prove a causal effect, but the association is striking.
Advera Health's Evidex platform is used by the pharmacovigilance departments within pharmaceutical companies to detect, validate, and analyze drug safety signals. Much of that analysis is done at the drug-AE level, combining various data sources like spontaneous reporting (FAERS, VigiBase, a company's own ISCR database), clinical trial results, social media monitoring, and claims/EHR data, to better understand and characterize a signal.
However, the platform also has the ability to aggregate data at the AE level alone, allowing users to then drill down to the drugs, mechanisms of action (MoA), classes, and indications where that AE has been reported.
Below are screen shots taken directly from Evidex that highlight some of this analysis on depression, as a drug adverse event. Feel free to get in touch with us to learn more.