An evidence aggregation platform is a web based software-as-a-service (SaaS) application that takes multiple, disparate sources of data, or evidence, and combines those data together using analytics to create new insight.
For example, an evidence aggregation platform can read adverse event data points from multiple clinical trial results and perform on-demand meta-analyses to better understand side effect rates for drugs. The evidence aggregation platform can then compare side effect rates from clinical trial results to side effect rates found in real world data such as pharmacy claims data or electronic health records (EHR).
In short, an evidence aggregation platform allows users to analyze efficacy and safety throughout a drug’s life-cycle using clinical trial results and real world data.
For pharmaceutical companies, this combination of data helps to support commercial planning, competitive intelligence, and health outcomes and economics research (HEOR) by providing objective, in-depth clinical and real world data about current and future markets. It also helps to benchmark evidence to individual market competitors and the market as a whole.
For managed care organizations, such as payers, health plans, and health systems, it provides a more efficient way of gathering data for evidence reviews, saving the time it typically takes to review an individual drug. Additionally, it delivers a way to better utilize internal data as well as benchmark those data to broader databases.
Although an evidence aggregation platform can take many shapes, Advera Health has defined three main categories: Data agnostic, closed curated, and hybrid.
Data agnostic evidence aggregation platforms are completely customizable and use client supplied data sources to power the software. These data could include clinical trial results generated from a recent phase III trial via electronic data capture, data from a client’s PBM, third-party licensed data, or really anything else that could be potentially useful. The customizability of a data agnostic solution is its strength, but also its weakness. Setup and technical specifications can be complicated and time consuming, not to mention expensive. Furthermore, the nature of customization makes it so it typically can solve a specific need very well, but its utility across a variety of use cases is less impactful.
Closed curated evidence aggregation platforms are completely standardized systems that offer datasets and sources that that are loaded to the platform by the vendor. The data are typically sourced from disparate publically available repositories, or licensed from other third-parties. The data are compiled on the platform for ease of consumption. Drug information databases and traditional market research platforms fall into this category. The benefit of a closed curated platform is that it is quick and easy to set up, as data are already preloaded and are often broad-based, put together in a way to solve a variety of issues. The downside of a closed curated platform is that it is very difficult to find the “perfect mix” of data sources that an organization needs. Closed curated platforms also fail to offer the option of using internal data, such as a health plan’s own pharmacy claims or other real world data sources a pharmaceutical company already licenses.
Hybrid evidence aggregation platforms are a mix between data agnostic and closed curated platforms, and in most cases offer the best of both types of solutions, with limited downside. An example of a hybrid platform would be one that presents vendor curated data, such as annotated data from curated clinical trial results, FDA Adverse Event Reporting System (FAERS) data, and then also incorporates client licensed claims data, or internal pharmacy benefit claims. Hybrid systems can provide unique datasets that a user would not be able to gather themselves, but still offer the benefit of customization.
Evidence aggregation platforms are becoming a vital source of intelligence for various healthcare decision makers in both pharmaceutical companies and managed care organizations.
Advera Health’s Evidex™ is an evidence aggregation platform that makes evidence collection and generation easy though a simple to use, yet powerful web-based application. To learn more about specific use cases of evidence aggregation platform's like Evidex for pharmaceutical companies, managed care organizations, hospitals, and product liability insurers, download our new White Paper, Use Cases for a Pharmaceutical Evidence Aggregation Platform- Combining Clinical Trial Results with Real World Data.
Jim Davis, EVP Advera Health