The RxView Blog

Real world data, analytics, and insights for healthcare decision makers

Advera Health Analytics, Inc.

The Long Run

Posted by Brian Overstreet on January 26, 2016


It’s been a tough few weeks for music fans with the deaths of David Bowie to liver cancer and Glen Frey to complications from rheumatoid arthritis and ulcerative colitis.  These are just two of the millions of people worldwide suffering from these diseases, but I’m sure I’m not the only one who felt a sense of loss from the passing of these two men.  Both profoundly influenced my adolescence and early adulthood through their music. 

In the days following the news of Frey’s death, news stories emerged sourcing his longtime manager Irving Azoff and medical professionals unrelated to his treatment that assigned some degree of blame on Frey’s death to the medications he was taking to treat his conditions.

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Topics: Drug Safety, RxScore, Formulary

It’s Confirmed: FDA is Failing When it Comes to Drug Safety

Posted by Jim Davis on January 22, 2016

Recently a report by the U.S. Government Accountability Office (GAO), filed at the request of Representative Rosa DeLauro on December 15, 2015 was made public. The report’s focus was to better understand the rate at which drug applications were expedited using “fast track” and “breakthrough therapy” designations and if FDA was fulfilling its duty to properly track and analyze post-marketing monitoring for those drugs.

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Topics: Drug Safety, FDA

Shadow Pricing, Highway Robbery, and the Price of Drugs

Posted by Brian Overstreet on May 15, 2015


It’s often difficult to pinpoint the moment a revolution starts, but when it comes to the issue of drug pricing it’s quite possible that we’ll look back at December 6, 2013 as the day that everything changed.

That was the day that Gilead’s Sovaldi was approved for sale by the FDA.  Sovaldi’s launch – and its $84,000 price tag – set off a tsunami of media attention on the issue of medication costs.  Never mind that Sovaldi has an incredible cure rate, all of the attention fell squarely on it $84,000 price tag.

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Topics: Drug Safety, Big Pharma, cost review

Drug Safety Bandits

Posted by Jim Davis on April 17, 2015

 

Monday is Patriots’ Day and its one of my favorite days of the year.

Patriots’ Day is held on the third Monday in April commemorating the anniversary of the Battles of Lexington and Concord, the first battles of the Revolutionary War. It is also Marathon Monday, the day of the Boston Marathon. It’s a day the city takes a break from normal Monday routines to cheer on runners, watch the Red Sox at 11am, and generally have a really good time.

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Topics: Drug Safety, RxScore, Adverse Drug Effects

Trimming The Fat Off Of Post-Marketing Drug Safety

Posted by Jim Davis on April 8, 2015

 

On March 16th the Wall Street Journal’s Health & Wellness section ran an article searching for answers on why sales of the new generation of weight-loss medications are slower than expected. The general conclusion is that the “P’s” in the healthcare value chain – patients, prescribers, and payers, perceive the drugs to have major safety concerns regardless of the FDA’s enforcement of more stringent approval paths.

So why do these safety concerns persist, even with a stricter FDA?

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Topics: Drug Safety, Wall Street Journal

The Cost of Drug Safety

Posted by Brian Overstreet on March 27, 2015

 

This week we were able to answer a question that has long puzzled the healthcare industry – what are the total costs of prescribing a particular drug? Our launch of RxCost™ provides an answer by allowing a look into a group of comparator drugs to see which has the most expensive side effects and, by extension, is least safe.

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Topics: Drug Safety, cost review

RxOutcome – A New Paradigm in Drug Safety

Posted by Bob Kyle on February 20, 2015

 

I’m pleased to share the news that this week we launched RxOutcome.

RxOutcome is a powerful new dashboard on the AdverseEvents Explorer platform that allows our clients to compare drugs across an indication, class, or mechanism of action.

With RxOutcome, subscribers can now compare actual incidence rates and patient outcome rates of a group of medications to see which drug is the safest option or which drug causes particular safety issues versus others in its peer group.

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Topics: Drug Safety, Comparable Effectiveness Research

Data, Disproportionality, & Drug Safety Communications

Posted by Andrea Demakas on October 30, 2014


Last week, pharmacovigilance news outlets announced the confirmation of one case of a serious adverse reaction from the multiple sclerosis (MS) drug Tecfidera. Reuters noted that this coincided with a 7 percent drop in Biogen Idec shares. The point of discussion here is a rare but serious brain infection called progressive multifocal leukoencephalopathy (PML). This adverse reaction led to the market withdrawal of Tysabri in 2005, and has been associated with other MS drugs as well. Tysabri was returned to the market after increased safety measures were put in place, including a risk minimization program. In 2012, the FDA posted a Drug Safety Communication stating a Boxed Warning would be added to another MS drug, Adcetris, after just 3 cases of PML were reported in patients taking this drug.

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Topics: Drug Safety

Moneyball for Drug Safety

Posted by Brian Overstreet on October 23, 2014


As an entrepreneur, one of the first things people always ask in the early days of a new business is, “what’s your 1-line pitch.” While it’s kind of silly to try to summarize everything about a new company in a single sentence (or, better yet, 3-4 words), it’s also vitally important. Being able to quickly convey the basic concept underlying a new venture is the first step in almost any conversation – with key early employees, potential investors, and pilot clients. The one line pitch opens the door for the longer “elevator pitch”. A successful elevator pitch can lead to a longer, more meaningful conversation. But without that 1-liner to start, you’re working upstream. In short, pitching a new business is a lot like dating – you need to have a strong opening line.

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Topics: Drug Safety, AdverseEvents, Inc

How New-Agers and Hipsters are Popularizing Drug Safety

Posted by Andrea Demakas on September 5, 2014


I’m not usually one to keep up with the latest trends, but I have been noticing how some of the fads from the past couple of years could actually make drug safety seem cool to the general public. Yes, I said it. We’re probably going to be extremely popular after this blog post goes out.

Hipsters are like cool nerds, with hats and extravagant mustaches. New-agers are like health nuts, with the addition of conspiracy theories and healing crystals. Are you starting to see where I am going with this? It’s okay if you don’t -- some people may think I’m making quite a leap. Let me explain.

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Topics: Drug Safety, Big Pharma, Pharmacovigilance

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